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Filtered Search Results
Medchemexpress LLC Bromocriptine mesylate | 22260-51-1 | 99.9% | 10 MG
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Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist that binds to the D2 dopamine receptor with a pKi of 8.05. It is permeable to the blood-brain barrier.
- Potent dopamine D2/D3 receptor agonist
- Binds D2 dopamine receptor with pKi of 8.05
- Permeable to the blood-brain barrier
- Stimulates [35S]-GTPγS binding at D2 dopamine receptor expressed in CHO cells with pEC50 of 8.15±0.05
- Strong inhibitor of brain nitric oxide synthase (NOS) (IC50=10±2 μM)
- Poorly active towards inducible macrophage NOS (IC50>100 μM)
- Potent inhibitor of CYP3A4 with a calculated IC50 value of 1.69 μM
- Demonstrates significant anti-immobility action in forced swimming test (FST) and tail suspension test (TST) in mice
- Potentiates the anti-immobility action of MPE
- Decreases static mechanical allodynia (SMA) score in rats
- Induces a significant, dose-dependent decrease in pain scores in the CCI-IoN group
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Medchemexpress LLC Almonertinib (mesylate) | 2134096-06-1 | 99.7% | 621.75 | 1 ML
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Almonertinib mesylate is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor. It shows high selectivity for EGFR-sensitizing and T790M resistance mutations, with inhibitory activity against T790M, T790M/L858R, and T790M/Del19. It is used for the research of non-small cell lung cancer (NSCLC). This compound can also inhibit other EGFR sensitive mutations, including G719X, del19, L858R, and L861Q.
- Orally available inhibitor
- Irreversible, third-generation EGFR tyrosine kinase inhibitor
- High selectivity for EGFR-sensitizing and T790M resistance mutations
- Inhibitory activity against T790M, T790M/L858R, and T790M/Del19
- Less effective against wild type EGFR
- Used for non-small cell lung cancer research
- Can inhibit other EGFR sensitive mutations like G719X, del19, L858R, and L861Q
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Medchemexpress LLC DIHYDROERGOCRISTINE 25 mg
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DIHYDROERGOCRISTINE 25MG
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Medchemexpress LLC Firmonertinib mesylate | 2130958-55-1 | 100.0% | 664.70 | 50 MG
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Firmonertinib mesylate is an orally active, mutant-selective, and blood-brain barrier penetrant EGFR inhibitor. It inhibits EGFR active mutations as well as the T790M acquired resistant mutation. It has potential for the research of cancer diseases, especially advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation.
- Orally active
- Mutant-selective
- Blood-brain barrier penetrant EGFR inhibitor
- Inhibits EGFR active mutations and T790M acquired resistant mutation
- Potential for research of cancer diseases, especially advanced NSCLC with EGFR ex20ins mutation
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Medchemexpress LLC Dihydroergocristine mesylate | 24730-10-7 | MFCD00153792 | ≥98.0% | 707.84 | C36H45N5O8S | 10 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Dihydroergocristine mesylate is a research reagent reported to act as a γ-secretase inhibitor; it reduces production of amyloid-β peptides and binds directly to γ-secretase and nicastrin. It is supplied as the mesylate salt for use in neuroscience and Alzheimer's disease research.
- Acts as a γ-secretase inhibitor.
- Reduces production of amyloid-β peptides.
- Binds directly to γ-secretase and nicastrin.
- Supplied as the mesylate salt.
- Available in small research quantities suitable for analytical or in-vitro studies.
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Ambeed AMBEED
5000950088 1-ACETYLINDOLINE-5-CARBO 100MG
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Ambeed AMBEED
5000950354 5-METHYLQUINOLINE-3-CARBO 10MG
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Aobchem 2-Fluoro-5-(morpholine-4-carbonyl)phenylboronic acid | ≥97% | CAS 1072951-41-7 | C11H13BFNO4 | 1g
2-Fluoro-5-(morpholine-4-carbonyl)phenylboronic acid | ≥97% | CAS 1072951-41-7 | C11H13BFNO4 | 1g
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Aobchem 2-Fluoro-5-(morpholine-4-carbonyl)phenylboronic acid | ≥97% | CAS 1072951-41-7 | C11H13BFNO4 | 250mg
2-Fluoro-5-(morpholine-4-carbonyl)phenylboronic acid | ≥97% | CAS 1072951-41-7 | C11H13BFNO4 | 250mg
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Apexbio Technology LLC NSC 74859 501919-59-1 200mg
NSC 74859 (CAS 501919-59-1) also known as S3I-201 is a selective inhibitor of the signal transducer and activator of transcription 3 (Stat3) pathway S3I-201 disrupts Stat3 DNA-binding activity exhibiting an IC50 of 86 M in vitro with minimal inhibitory effects on Stat1 and Stat5 It also impedes the formation of Stat1-Stat3 and Stat1-Stat1 complexes with IC50 values of 160 M and 300 M respectively In NIH 3T3/v-Src fibroblasts S3I-201 reduces constitutive Stat3 activation and pTyr-705 Stat3 levels induces apoptosis at 30 100 M and downregulates cyclin D1 Bcl-xL and survivin expression This compound is widely utilized in research to interrogate Stat3 function in cellular transformation and oncogenic signaling pathways
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Aobchem 2 2-Difluoroethylmethane sulfonate | ≥95% | CAS 163035-65-2 | C3H6F2O3S | 1g
2 2-Difluoroethylmethane sulfonate | ≥95% | CAS 163035-65-2 | C3H6F2O3S | 1g
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Aobchem 2 3-Dihydrobenzofuran-7-carbaldehyde | 95% | CAS 196799-45-8 | C9H8O2 | 250mg
2 3-Dihydrobenzofuran-7-carbaldehyde | 95% | CAS 196799-45-8 | C9H8O2 | 250mg
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Aobchem 5 6-Dimethoxy-pyridine-2-carboxylic acid | ≥95% | CAS 324028-89-9 | C8H9NO4 | 500mg
5 6-Dimethoxy-pyridine-2-carboxylic acid | ≥95% | CAS 324028-89-9 | C8H9NO4 | 500mg
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Aobchem (3-Trifluoromethylphenyl)carbamic acid tert-butyl ester | ≥95% | CAS 109134-07-8 | C12H14F3NO2 | 1g
(3-Trifluoromethylphenyl)carbamic acid tert-butyl ester | ≥95% | CAS 109134-07-8 | C12H14F3NO2 | 1g
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Aobchem 9-(3 5-Dibromophenyl)-9H-carbazole | ≥97% | CAS 750573-26-3 | C18H11Br2N | 25g
9-(3 5-Dibromophenyl)-9H-carbazole | ≥97% | CAS 750573-26-3 | C18H11Br2N | 25g
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